Toward in vivo Digital Circuits
Motivation
Approach
Key: Biological Inverters
Digital Circuits
Outline
Components of Inversion
Stage I: Cooperative Binding
Stage II: Transcription
Stage III: Translation
Putting it together
Model
Steady-State Behavior
Inverter’s Dynamic Behavior
Connect: Ring Oscillator
Memory: RS Latch
Measuring a Signal
Measuring a Transfer Curve
Measuring a Transfer Curve II
Models vs. Reality
The Transfer Band
Microbial Circuit Design
Matching Gates
Modifications to Gates
Modifying Repression
Modifying Promoter
BioSpice
BioSpice Simulation
Limits to Circuit Complexity
Related Work
Conclusions + Future Work
Inverter: Chemical Reactions
Email: rweiss@ai.mit.edu
Home Page: http://www.swiss.ai.mit.edu/~rweiss